90% of ibuprofen is metabolised to inactive compounds during the liver, primarily by glucuronidation, to provide two metabolites - a hydroxylated compound as well as a carboxylated compound. Evident volume of distribution is 0.fourteen L/kg. Ibuprofen and its metabolites commonly cross the placental barrier in pregnant animals (rabbits and rats). https://brufenplus64161.webbuzzfeed.com/30222208/brufen-plus-an-overview