Abstract Background The dynamics of histone post-translational modifications (PTMs) are sparsely described. especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs). Methods Here we time-resolve the response of cells to SUV4-20 methyltransferase inhibition and unbiasedly quantitate the dynamic response of histone H4 PTMs a... https://www.getpureroutine.com/