There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent pain transmission and generate analgesia. Hence, medication like clonidine that target alpha-two receptors can affect the transmission of soreness. Combining these heart medicine with clonidine can https://www.proleviate.com/post/the-new-pain-killer-conolidine