Vicodin and OxyContin are pain-relieving medicines that a doctor can prescribe. They're both for moderate to severe pain. Both medicines are called 'opioids'. Opioids work by changing the way your brain and nervous system react to and feel the pain. While they are similar, they differ as to what is the best medicine for pain relief. Vicodin is used as a short-term pain reliever. https://secondnewlife.com/vicodin-vs-oxycontin/